How to Use Vitamin C Serum Without Irritation (Complete Guide for Sensitive Skin) Featured Snippet (Direct Answer) To use vitamin C serum without irritation, apply a low-concentration, well-formulated vitamin C on clean, dry skin, followed by a hydrating serum or moisturizer. Start slowly (2–3 times per week), avoid combining with strong actives initially, and choose … Continue reading How to Use Vitamin C Serum Without Irritation (Complete Guide for Sensitive Skin)